Liquisolid Compacts: An Approach to Enhance the. Dissolution Rate of Nimesulide. Srinivas Vaskula, Sateesh Kumar Vemula, Vijaya Kumar. PDF | ABSTACT Liquisolid compacts were used to formulate water insoluble drugs in non volatile solvents and convert into acceptable flowing. PDF | The aim of this study was to investigate the use of liquisolid technique in improving the dissolution of Glimepiride in a solid dosage form. This study was.
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On the other hand, if a solid water-insoluble drug is formulated, it should be initially dissolved or suspended in suitable nonvolatile solvent system to produce drug solution or drug suspension of desired concentration. With these technique liquids dosage forms such as solutions or suspensions of poorly soluble drugs in a non-volatile liquid vehicle are converted into acceptably free flowing and compressible powders by simple physical blending with selected excipients named the carrier and the coating material.
From the dissolution profiles, it can be seen that all liquisolid formulations significantly improved drug dissolution compared to conventional tablets. Formulations containing showed good flowability than formulations containing. A liquid lipophilic drug can be liquiolid into liquisolid system without being further modified. Ann Jose ankara escort. The and for liquid vehicles were used to calculate.
Formulation and Evaluation of Liquisolid Compacts for Olmesartan Medoxomil
The excipient and coating material are to be taken into definite ratios so as to retain the accepted amount of liquid to be converted into solid. To receive news and publication updates for Journal of Drug Delivery, enter your email address in the box below.
Agri and Aquaculture Journals Dr. The tensile strength of the tablet was also fompacts. To calculate the required amounts of powder excipients including both carrier and coating materials a mathematical approach for the formulation of A powder may be able to retain only limited amounts of liquid while maintaining acceptable flow and compression properties.
Authors and affiliation s: Formulation containing Neusilin-Neusilin and Neusilin- Aerosil showed no disintegration while all other formulations showed disintegration up to seconds. The several mechanisms by which solubility enhancement takes place have been postulated for liquisolid systems.
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Liquisolid compacts are acceptably flowing and compressible powder forms of liquid medications. New chemical entities are often macromolecules with high lipophillicity show poor solubility and high permeability and present a technological challenge mainly due to their poor bioavailabilitywhich leads to poor absorption. These peaks can be considered as characteristic peaks of olmesartan medoxomil lquisolid were not affected and prominently observed in IR spectra of olmesartan medoxomil along with oil and carrier materials shown in Figure 4 b.
The solubility is an important factor in liquisolid systems, as higher solubility of drug in liquid vehicle can loquisolid to higher dissolution rates since the drug will be more molecularly dispersed and more surface of drug will be exposed to the dissolution media.
FTIR spectroscopy helps to determine any chemical interaction between drug ckmpacts excipients used in formulation. A lesser amount of Neusilin liquizolid required to adsorb the same amount of liquid vehicle than Avicel and Fujicalin, which lowered the weight of tablet.
For liquisolid mixture, the endothermic peak of the drug completely disappeared indicating that the drug is completely solubilized and molecularly dispersed with excipients within liquisolid system. Can’t read the image? The angle of repose of powder blend was determined by fixed height funnel method. Journal conpacts Drug Delivery. Fujicalin and Neusilin are used as carrier materials instead of Avicel, the liquid adsorption capacity increases by many folds.
Aerosil is known to be hydrophobic in nature, which retards the flow properties. Composition of liquids solid compacts batches is shown in Table 1. It is highly lipophilic log P 5. Dissolution profile of liquisolid compacts was compared with marketed tablet formulation.
Solubility of CBZ was determined in different non volatile solvents to finalise vehicle having maximum solubility. It can be concluded from this study that novel porous carriers are superior to traditional carriers in liquisolid systems and are suitable for loading high dose drugs like CBZ. The flowability improvement can be attributed to the high porosity and high specific surface area of these excipients, which allows penetration of liquid into the particle pores resulting in a weight gain of individual particle accompanied by better flow properties.
A powder may be able to retain only limited amounts of liquid while maintaining acceptable flow and compression properties. Abstract Olmesartan medoxomil is an angiotensin type II receptor blocker, antihypertensive agent, administered orally. The results of various flow parameters are shown in Table 3.
Six tablets from each formulation were tested for hardness. The interaction between drug and excipients was characterized by DSC and FT-IR studies, which showed that there is no interaction between drug and excipients. Related article at PubmedScholar Google. To this liquid medication, the calculated amount of the carrier was added by continuous mixing in the mortar.
The flowable liquid retention potential was calculated using the following equation: The less drug concentration in the vehicle means more fraction of the drug is liable to be in the liquid solution form i. The solubility of CBZ in polyethylene glycol was found to be greater than the other solvents.
Olmesartan appears to be more soluble in Acrysol EL than other vehicles. Usually, microcrystalline cellulose and colloidal silica are used as the carrier and the coating material, respectively. Due to significantly increased wetting properties and surface area of the drug particles available for dissolution, liquisolid tablets were expected to enhance drug release characteristics and, consequently, improved oral bioavailability.
Most of hydrophobic drugs show very poor dissolution in the gastro intestinal tract, leading to erratic and incomplete drug absorption.
In the formulation development process solubility of active compound is one of the main criteria considered before deciding the dosage form. Several techniques have been reported to improve drug solubility, among which the liquisolid technology is one of the most promising approaches.
Figures 3 a and 3 b show the thermogram for olmesartan medoxomil and liquisolid mixture. The flow property obtained by Neusilin was good and remains unaffected at such low amount. The following materials were gifted by Abitec Corp. Subscribe to Table of Contents Alerts. Among the newly developed drugs which are meant for oral administration, around half exhibit solubility problem in water, which affects the formulation development process.